Replicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection
Identifieur interne : 000830 ( Main/Exploration ); précédent : 000829; suivant : 000831Replicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection
Auteurs : Wan Beom Park [Corée du Sud] ; Leo L. M. Poon [République populaire de Chine] ; Su-Jin Choi [Corée du Sud] ; Pyoeng Gyun Choe [Corée du Sud] ; Kyoung-Ho Song [Corée du Sud] ; Ji Hwan Bang [Corée du Sud] ; Eu Suk Kim [Corée du Sud] ; Hong Bin Kim [Corée du Sud] ; Sang Won Park [Corée du Sud] ; Nam Joong Kim [Corée du Sud] ; Malik Peiris [République populaire de Chine] ; Myoung-Don Oh [Corée du Sud]Source :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2018.
Descripteurs français
- KwdFr :
- Appareil respiratoire (physiopathologie), Appareil respiratoire (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Excrétion virale, Expectoration (virologie), Humains, Infections à coronavirus (physiopathologie), Infections à coronavirus (virologie), Réaction de polymérisation en chaine en temps réel, Réplication virale, Transcription inverse.
- MESH :
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- physiopathologie : Appareil respiratoire, Infections à coronavirus.
- virologie : Appareil respiratoire, Expectoration, Infections à coronavirus.
- Excrétion virale, Humains, Réaction de polymérisation en chaine en temps réel, Réplication virale, Transcription inverse.
English descriptors
- KwdEn :
- Coronavirus Infections (physiopathology), Coronavirus Infections (virology), Humans, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Real-Time Polymerase Chain Reaction, Respiratory System (physiopathology), Respiratory System (virology), Reverse Transcription, Sputum (virology), Virus Replication, Virus Shedding.
- MESH :
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- physiopathology : Coronavirus Infections, Respiratory System.
- virology : Coronavirus Infections, Respiratory System, Sputum.
- Humans, Real-Time Polymerase Chain Reaction, Reverse Transcription, Virus Replication, Virus Shedding.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) sub-genomic mRNAs indicates that the virus is replicative. Sub-genomic mRNA was detected in lower respiratory tract specimens for up to 4 weeks after symptoms developed. In upper respiratory tract specimens, the detection of sub-genomic mRNA and genomic RNA did not correlate.
Url:
DOI: 10.1016/j.ijid.2018.05.003
PubMed: 29753119
PubMed Central: 7110884
Affiliations:
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Le document en format XML
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M." last="Poon">Leo L. M. Poon</name><affiliation wicri:level="1"><nlm:aff id="aff0015">School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Su Jin" sort="Choi, Su Jin" uniqKey="Choi S" first="Su-Jin" last="Choi">Su-Jin Choi</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung-Ho" last="Song">Kyoung-Ho Song</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0010">Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><affiliation wicri:level="1"><nlm:aff id="aff0015">School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0010">Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus Infections (physiopathology)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Real-Time Polymerase Chain Reaction</term><term>Respiratory System (physiopathology)</term><term>Respiratory System (virology)</term><term>Reverse Transcription</term><term>Sputum (virology)</term><term>Virus Replication</term><term>Virus Shedding</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Appareil respiratoire (physiopathologie)</term><term>Appareil respiratoire (virologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Excrétion virale</term><term>Expectoration (virologie)</term><term>Humains</term><term>Infections à coronavirus (physiopathologie)</term><term>Infections à coronavirus (virologie)</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Réplication virale</term><term>Transcription inverse</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory System</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Expectoration</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory System</term><term>Sputum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Real-Time Polymerase Chain Reaction</term><term>Reverse Transcription</term><term>Virus Replication</term><term>Virus Shedding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Excrétion virale</term><term>Humains</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Réplication virale</term><term>Transcription inverse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Middle East respiratory syndrome coronavirus (MERS-CoV) sub-genomic mRNAs indicates that the virus is replicative.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Sub-genomic mRNA was detected in lower respiratory tract specimens for up to 4 weeks after symptoms developed.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">In upper respiratory tract specimens, the detection of sub-genomic mRNA and genomic RNA did not correlate.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name></author><author><name sortKey="Albarrak, A M" uniqKey="Albarrak A">A.M. Albarrak</name></author><author><name sortKey="Omrani, A S" uniqKey="Omrani A">A.S. Omrani</name></author><author><name sortKey="Albarrak, M M" uniqKey="Albarrak M">M.M. Albarrak</name></author><author><name sortKey="Farah, M E" uniqKey="Farah M">M.E. Farah</name></author><author><name sortKey="Almasri, M" uniqKey="Almasri M">M. Almasri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name></author><author><name sortKey="Assiri, A M" uniqKey="Assiri A">A.M. Assiri</name></author><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A. Al-Tawfiq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Min, C K" uniqKey="Min C">C.K. Min</name></author><author><name sortKey="Cheon, S" uniqKey="Cheon S">S. Cheon</name></author><author><name sortKey="Ha, N Y" uniqKey="Ha N">N.Y. Ha</name></author><author><name sortKey="Sohn, K M" uniqKey="Sohn K">K.M. Sohn</name></author><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name></author><author><name sortKey="Aigerim, A" uniqKey="Aigerim A">A. Aigerim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oh, M D" uniqKey="Oh M">M.D. Oh</name></author><author><name sortKey="Park, W B" uniqKey="Park W">W.B. Park</name></author><author><name sortKey="Choe, P G" uniqKey="Choe P">P.G. Choe</name></author><author><name sortKey="Choi, S J" uniqKey="Choi S">S.J. Choi</name></author><author><name sortKey="Kim, J I" uniqKey="Kim J">J.I. Kim</name></author><author><name sortKey="Chae, J" uniqKey="Chae J">J. Chae</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, W B" uniqKey="Park W">W.B. Park</name></author><author><name sortKey="Perera, R A" uniqKey="Perera R">R.A. Perera</name></author><author><name sortKey="Choe, P G" uniqKey="Choe P">P.G. Choe</name></author><author><name sortKey="Lau, E H" uniqKey="Lau E">E.H. Lau</name></author><author><name sortKey="Choi, S J" uniqKey="Choi S">S.J. Choi</name></author><author><name sortKey="Chun, J Y" uniqKey="Chun J">J.Y. Chun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sawicki, S G" uniqKey="Sawicki S">S.G. Sawicki</name></author><author><name sortKey="Sawicki, D L" uniqKey="Sawicki D">D.L. Sawicki</name></author><author><name sortKey="Siddell, S G" uniqKey="Siddell S">S.G. Siddell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Who" uniqKey="Who">WHO</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Fan, R Y" uniqKey="Fan R">R.Y. Fan</name></author><author><name sortKey="Lau, C C" uniqKey="Lau C">C.C. Lau</name></author><author><name sortKey="Wong, E Y" uniqKey="Wong E">E.Y. Wong</name></author><author><name sortKey="Joseph, S" uniqKey="Joseph S">S. Joseph</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>République populaire de Chine</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name></region><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name><name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name><name sortKey="Choi, Su Jin" sort="Choi, Su Jin" uniqKey="Choi S" first="Su-Jin" last="Choi">Su-Jin Choi</name><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name><name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung-Ho" last="Song">Kyoung-Ho Song</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L. M." last="Poon">Leo L. M. Poon</name></noRegion><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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